MOLECULAR CYTOGENETIC CHARACTERISTIC OF IGH GENES REARRANGEMENTS IN PATIENTS WITH B-CELL NON-HODGKIN’S LYMPHOMAS
Sit'ko Valentina Vital'evna, Bebeshko Vladimir Grigor'evich, Minchenko Zhanna Nikolaevna, Misharina Zhanna Anatol'evna
National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Kiev
Bogomolets National Medical University, Kiev, Ukraine
Abstract. In the article the results of the molecular and cytogenetic studies of 42 patients with B-cell non-Hodgkin’s lymphomas (B-NHL) are presented. With the help of I-FISH method the authors reveal IGH genes rearrangements, which are of great diagnostic and prognostic importance for patients. It is concluded that the identification of translocations involving IGH genes will allow oncologists-hematologists to verify diagnosis and to optimize the treatment strategy of patients with B-NHL to overcome resistance in the conditions of the use of modern chemotherapy programs.
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