Abstract. Creation of long-acting pharmaceutical forms is a promising tendency in modern pharmacology. The realization of pharmaceutical forms with modified release in the area affected by a pathological process allows decreasing sharply undesirable body reactions to medicamental treatment, reducing the therapeutic doze of a medicine and the frequency of its injection. On the basis of the Department of Biochemistry and Biotechnology of the Faculty of Biology and Chemistry of the Udmurt State University they conducted experiments on gentamycin modification by vinylpyrrolidone copolymer with acrolein diacetal for the purpose of studying the antimicrobial and pharmacokinetic parameters of this conjugate.
Key words and phrases: антибиотики, полимеры, модификация, пролонгированные свойства, антимикробная активность, период полувыведения, antibiotics, polymers, modification, long-acting properties, antimicrobial activity, elimination half-life
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