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License Agreement on scientific materials use.
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MOLECULAR CYTOGENETIC CHARACTERISTIC OF
IGH GENES REARRANGEMENTS IN PATIENTS WITH B-CELL NON-HODGKIN’S LYMPHOMAS
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Valentina Vital'evna Sit'ko
National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Kiev
Vladimir Grigor'evich Bebeshko
National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Kiev
Zhanna Nikolaevna Minchenko
National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Kiev
Zhanna Anatol'evna Misharina
Bogomolets National Medical University, Kiev, Ukraine
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Submitted:
June 1, 2015
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Abstract.
In the article the results of the molecular and cytogenetic studies of 42 patients with B-cell non-Hodgkin’s lymphomas (B-NHL) are presented. With the help of I-FISH method the authors reveal IGH genes rearrangements, which are of great diagnostic and prognostic importance for patients. It is concluded that the identification of translocations involving IGH genes will allow oncologists-hematologists to verify diagnosis and to optimize the treatment strategy of patients with B-NHL to overcome resistance in the conditions of the use of modern chemotherapy programs.
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Key words and phrases:
В-клеточные неходжкинские лимфомы
IGH транслокации
ген FGFR3
ген MYC
ген CCND1
ген MAF
ген MALT1
B-cell non-Hodgkin’s lymphoma
IGH genes translocations
FGFR3 gene
MYC gene
CCND1 gene
MAF gene
MALT1 gene
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