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SOURCE:   Almanac of Modern Science and Education. Tambov: Gramota, 2014. 4. P. 128-133.
SCIENTIFIC AREA: Medical Sciences
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PATHOPHYSIOLOGICAL CHANGES IN EXPERIMENTAL RADICULAR ISCHEMIA CONDITIONS AND THEIR NEUROPROTECTIVE CORRECTION

Pogorelov Vadim Viktorovich, Zhukov Viktor Ivanovich
Central Clinical Hospital of the Ukrainian Railway, Kharkov

Kharkiv National Medical University, Ukraine


Abstract. In the experiment on 30 Wistar rats the indexes of lipid peroxidation and antioxidant protection, the level of hormones - cortisol and melatonin - and also leptin influenced by alpha-lipoic acid and melatonin are studied. The injection of alpha-lipoic acid and melatonin into the experimental animals was accompanied by the change in the parameters of antioxidant protection - cortisol, melatonin and leptin. The changes were more marked in case of the combination of these remedies.
Key words and phrases: , , , - + , discogenic radicular ischemia, lipid peroxidation, antioxidant protection, alpha-lipoic acid + melatonin.
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