GRAMOTA Publishers suggests publishing your scientific articles in periodicals
Pan-ArtPedagogy. Theory & PracticePhilology. Theory & PracticeManuscript

Archive of Scientific Articles

SOURCE:    Almanac of Modern Science and Education. Tambov: Gramota, 2015. № 7. P. 114-116.
SCIENTIFIC AREA:    Biological Sciences
Procedure of Scientific Articles Publication | To Show Issue Content | To Show All Articles in Section | Subject Index

License Agreement on scientific materials use.


Sit'ko Valentina Vital'evna, Bebeshko Vladimir Grigor'evich, Minchenko Zhanna Nikolaevna, Misharina Zhanna Anatol'evna
National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Kiev

Bogomolets National Medical University, Kiev, Ukraine

Abstract. In the article the results of the molecular and cytogenetic studies of 42 patients with B-cell non-Hodgkin’s lymphomas (B-NHL) are presented. With the help of I-FISH method the authors reveal IGH genes rearrangements, which are of great diagnostic and prognostic importance for patients. It is concluded that the identification of translocations involving IGH genes will allow oncologists-hematologists to verify diagnosis and to optimize the treatment strategy of patients with B-NHL to overcome resistance in the conditions of the use of modern chemotherapy programs.
Key words and phrases: В-клеточные неходжкинские лимфомы, IGH транслокации, ген FGFR3, ген MYC, ген CCND1, ген MAF, ген MALT1, B-cell non-Hodgkin’s lymphoma, IGH genes translocations, FGFR3 gene, MYC gene, CCND1 gene, MAF gene, MALT1 gene
Open the whole article in PDF format. Free PDF-files viewer can be downloaded here.
  1. Chetverina E. V., Chetverin A. B. Nanokolonii i diagnostika onkologicheskikh zabolevanii, assotsiirovannykh s khromosomnymi translokatsiyami // Uspekhi biologicheskoi khimii. 2010. T. 50. S. 387-446.
  2. Chekhun V. F., Yurchenko O. V. Sovremennye molekulyarno-biologicheskie aspekty V-kletochnykh nekhodzhkinskikh zlokachestvennykh limfom // Onkologiya. 2007. T. 9 (7). S. 278-279.
  3. Adhikary S., Eilers M. Transcriptional Regulation and Transformation by MYC Proteins // Nature Reviews. 2005. Vol. 6. P. 635-645.
  4. Bea S. Cyclin D1 Transcriptional Activation in MCL // Blood. 2014. Vol. 123 (13). P. 1979-1980.
  5. Kim J. I., Li T., Ho I. C., Grusby M. J., Glimcher L. H. Requirement for the c-Maf Transcription Factor in Crystallin Gene Regulation and Lens Development // Proceedings of the National Academy of Sciences of the USA. 1999. Vol. 96 (7). P. 3781-3785.
  6. Kridel R., Sehn L. H., Gascoyne R. D. Pathogenesis of Follicular Lymphoma // Journal of Clinical Investigation. 2012. Vol. 122 (10). P. 3424-3431.
  7. Turner N., Grose R. Fibroblast Growth Factor Signalling: from Development to Cancer // Nature Reviews Cancer. 2010. Vol. 10 (2). P. 116-129.
  8. Tzankov A., Xu-Monette Z. Y., Gerhard M., Visco C. Rearrangements of MYC Gene Facilitate Risk Stratification in Diffuse Large B-cell Lymphoma Patients Treated with Rituximab-CHOP // Modern Pathology. 2014. Vol. 27 (7). P. 958-971.
  9. Zhang S., Wei M., Liang Q. The t(14;18)(q32;q21)/IGH-MALT1 Translocation in Gastrointestinal Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) // Histopathology. 2014. Vol. 64 (6). P. 791-798.
  10. Zhou K., Xu D., Cao Y. C-MYC Aberrations as Prognostic Factors in Diffuse Large B-cell Lymphoma: a Meta-Analysis of Epidemiological Studies // PloS One. 2014. Vol. 9 (4). R. 1-9.

Procedure of Scientific Articles Publication | To Show Issue Content | To Show All Articles in Section | Subject Index

© 2006-2024 GRAMOTA Publishers

site development and search engine optimization (seo):