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SOURCE:    Almanac of Modern Science and Education. Tambov: Gramota, 2016. № 8. P. 75-79.
SCIENTIFIC AREA:    Biological Sciences
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ON CERTAIN CHARACTERISTICS OF MODIFIED GENTAMYCIN

Sasu Nursiya Vazikhovna
Udmurt State University


Abstract. Creation of long-acting pharmaceutical forms is a promising tendency in modern pharmacology. The realization of pharmaceutical forms with modified release in the area affected by a pathological process allows decreasing sharply undesirable body reactions to medicamental treatment, reducing the therapeutic doze of a medicine and the frequency of its injection. On the basis of the Department of Biochemistry and Biotechnology of the Faculty of Biology and Chemistry of the Udmurt State University they conducted experiments on gentamycin modification by vinylpyrrolidone copolymer with acrolein diacetal for the purpose of studying the antimicrobial and pharmacokinetic parameters of this conjugate.
Key words and phrases: антибиотики, полимеры, модификация, пролонгированные свойства, антимикробная активность, период полувыведения, antibiotics, polymers, modification, long-acting properties, antimicrobial activity, elimination half-life
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References:
  1. Varfolomeev S. D., Gurevich K. G. Biokinetika: prakticheskii kurs. M.: FAIR-PRESS, 1999. 720 s.
  2. Gosudarstvennaya farmakopeya Rossiiskoi Federatsii: v 5-ti ch. / Nauchnyi tsentr ekspertizy sredstv meditsinskogo primeneniya. Izd. 12-e. M., 2008. Ch. 1. 704 s.
  3. Egorov N. S. Osnovy ucheniya ob antibiotikakh: uchebnik. 6-e izd., pererab. i dop. M.: Nauka, 2004. 528 s.
  4. Korzhavykh E. Lekarstvennye formy s modifitsirovannym vysvobozhdeniem i deistviem // Rossiiskie apteki. 2003. № 4. S. 29-34.
  5. Panarin E. F., Nesterov V. V. Sintez i svoistva sopolimerov vinilpirrolidona s diatsetalem akroleina // Vysokomolekulyarnye soedineniya. 1978. T. 20. № 1 (B). S. 66-69.
  6. Reshed'ko G. K. Znachenie fermentativnoi modifikatsii aminoglikozidov v razvitii rezistentnosti u bakterii // Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya. 1999. T. 1. № 1. S. 40-50.
  7. Solovskii M. V., Nikol'skaya N. V. Soli antibiotika gentamitsina s karboksilsoderzhashchim sopolimerom N-vinilpirrolidona // Khimiko-farmatsevticheskii zhurnal. 2000. T. 34. № 11. S. 21-24.
  8. Tekhnologiya lekarstv: uchebnik dlya farmatsevticheskikh vuzov i fakul'tetov / per. s ukr.; pod red. A. I. Tikhonova. Khar'kov: NFAU, 2002. 704 s.
  9. Farmatsevticheskie i mediko-biologicheskie aspekty lekarstv: v 2-kh t. / pod red. I. M. Pertseva, I. A. Zupantsa. Khar'kov: UkrFA, 1999. T. 1. 442 s.
  10. Khananov E. A., Mizina P. G., Simakina A. A. Prolongirovannye lekarstvennye formy kak sposob snizheniya negativnykh vozdeistvii na chelovecheskii organizm // Izvestiya Samarskogo nauchnogo tsentra Rossiiskoi akademii nauk. 2009. T. 11. № 1 (6). S. 1321-1323.
  11. Khomyakov K. P. Prolongirovanie deistviya lekarstvennykh preparatov putem ispol'zovaniya ikh v smesi s polimerami ili prisoedineniya k polimeram // Uspekhi khimii. 1964. T. 33. № 9. S. 1051-1061.

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